id	first name	surname	city	e-mail	department	supervisor	work address	postal code	city	preferred language	present position	description of project (max 250 words)	subject for PhD studies	applicants from other faculties
3624	Shady	Younis	Uppsala	shady.younis@imbim.uu.se	IMBIM	Leif Andersson	Uppsala University	751 23 UPPSALA	Uppsala	english	PhD	I am studying the molecular functions of number of transcription factors such as ZBED6 and ZC3H11A.	Molecular Genetics	no
3627	Doreen	Schwochow	Uppsala	doreen.schwochow@slu.se	"SLU, Animal breeding and Genetics"	Leif Andersson	Box 597	75124	Uppsala	english	PhD student	"In my PhD project I am working on identifying genes, which are involved in feather color patterns in birds. Since the domestic chicken exhibits an astonishing variation in color patterns both across the body as well as on individual feathers they are the perfect study subjects for my project. I am aiming to identify the causative mutations of 4 to 5 pattern genes and investigate their mode of action by using a chicken melanocyte cell line obtained from feathers exhibiting the respective phenotype."	Genetic basis of color pattern genes in birds	yes
3631	Oskar	Clewe	Uppsala	oskar.clewe@farmbio.uu.se	Farmaceutisk Biovetenskap	Ulrika Simonsson	P.O. Box 591	75124	Uppsala	english	PhD Student	Pharmacokinetic and pharmacodynamic population modeling of drugs targeting tuberculosis.	Pharmacometrics	no
3632	Elin	Svensson	Uppsala	elin.svensson@farmbio.uu.se	Farmaceutisk biovetenskap	Mats Karlsson	Box 591	751 24	Uppsala	swedish or English	PhD-student	Population modelling of pharmacokinetics and pharmacodynamics of drugs for infectious diseases.	Pharmacometrics	no
3633	Oskar	Alskär	Upspala	oskar.alskar@farmbio.uu.se	Farmaceutisk biovetenskap	"Maria Kjellsson, Mats Karlsson"	P.O BOX 591	75124	Uppsala	swedish or English	Doktorand	Mixed-effects modeling of long-term disease progression and ivestigation of biomarkers for cardiovascular conditions in type 2 diabetes mellitus patients	Farmakometri	no
3641	KHURRAM	MAQBOOL	Uppsala	khurram.maqbool@slu.se	Animal Breeding and Genetics	Prof. Leif Andersson	"Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 570"	75123	Uppsala	english	Phd Student	Whole genome resequencing of Domestic Animals	Bioinformatics	yes
3642	Malin	Melin	Uppsala	malin.melin@imbim.uu.se	IMBIM	Kerstin Lindblad-Toh	"BMC, D11:3, Box 597"	751 23	Uppsala	swedish or English	Post doc	"My research focuses on identifying genetic risk factors underlying cancer (mainly mammary tumours), with the dog as a model for human cancer. We have performed a genome-wide association study followed by resequencing of the top associated regions and are using the data to find disease-causing variants. We hope to find new genes and pathways of importance for the development of mammary tumours in both dogs and humans."	Clinical molecular genetics	no
3644	Emma	Ivansson	Storvreta	emma.ivansson@imbim.uu.se	IMBIM	Kerstin Lindblad-Toh	IMBIM C11:3 Box 582	75123	Uppsala	swedish or English	"PostDoc at IMBIM, UU"	My present postdoc projects concern the genetics of canine diseases. We map susceptibility factors through GWAs and look for candidate mutations by resequencing. We also analyze whole genome sequence DNA sequence and whole genome expression data in order to understand the diseases.	Genetics of cervical cancer	no
3645	Sangeet	Lamichhaney	Uppsala	Sangeet.Lamichhaney@imbim.uu.se	IMBIM	Prof. Leif Andersson	"Uppsala biomedicinska centrum, BMC, Husarg. 3"	751 23	Uppsala	english	PhD Student	Study of genetic variation in Atlantic herring population	Molecular Genetics	no
3653	Maja	Arendt	Uppsala	maja-louise.arendt@imbim.uu.se	IMBIM	Kerstin Linblad-Toh	"Box 582, IMBIM"	75123	Uppsala	english	Post Doc	"Genetic studies in dogs to elucidate germ line mutations for diseases. Includes a heavy computational load in handling SNP data, next gen sequencing data, RNA seq data and whole genome sequencing of tumor versus normal tissues."	GWAS studies determining germline associations to disease using animal models	no
3656	Maria	Wilbe	Uppsala	maria.wilbe@slu.se	Husdjursgenetik	Göran Andersson	Husargatan 3	75124	Uppsala	swedish or English	PhD student	"The aim of my main project is to identify genetic risk factors for a Systemic Lupus Erythematousus (SLE) -related disease complex in the dog and also in human SLE. We are using different methods as GWAs, re-sequencing, trancriptome sequencing. Identified risk factors are validated with functional studies to identify pathways associated with the disease."	Molecular genetics	yes
3657	Fabiana	Farias	Uppsala	fabiana.farias@imbim.uu.se	IMBIM	Kerstin Lindblad-Toh	Department of Medical Biochemistry and microbiology	751 23	Uppsala	english	Post-doctoral	Mapping canine inherited diseases.	Molecular biology	no
3665	MERINA	SHRESTHA	UPPSALA	mesh0002@stud.slu.se	Animal Breeding and Genetics	Gabriella Lindgren	GERDA NILSSON VAG 2	75007	UPPSALA	english	PhD student	"The project involves identification of the chromosomal regions and subsequently genes and mutations associated with the complex disease, Insect bite hypersensitivity (IBH). IBH or summer eczema is the most common disease in horses worldwide. Meta analysis on horse data will be performed for the identification of the chromosomal region. Further, fine mapping will be performed using candidate gene method or resequencing. It has been shown that MHC class II cluster variants influence the susceptibility to IBH; hence whole genome sequencing will be performed to fine map the genes in MHC class II cluster. Detection of causative variant will assist in developing genetic tests that can be used for the welfare of the horses themselves and also in the breeding program."	Genetic studies on Insect bite hypersensitivity	yes
3735	Camille	Vong	Uppsala	camille.vong@farmbio.uu.se	Pharmaceutical Biosciences	Mats O Karlsson	Box 591	75124	Uppsala	english	PhD Student	"The aims of the thesis was to implement and evaluate methodology for optimising dose-finding designs and analyses based on quantitative dose-exposure-response models for both efficacy and toxicity, to simplify power-calculations based on clinical trial simulations by the development of a more time-efficient new power calculation method, to include ethical aspects by reducing the number of patient inclusion, to increase better study outcomes by acknowledging beforehand possible adverse effects in the prospective data analysis, to further develop Bayesian adaptive designs (e.g. CRM) in an optimal design approach and to apply and validate these developed methods to an oncology drug development project including combination therapy."	Design and analysis of oncology dose-finding studies	no
3736	Anders	Kristoffersson	Uppsala	anders.kristoffersson@farmbio.uu.se	Institutionen för farmaceutisk biovetenskap	Lena Friberg	Box 591	751 24	UPPSALA	swedish or English	Doktorand/Assistent	The development of optimized model based experimental designs of antibiotic time kill curve experiments. The optimization is carried out in the PopED optimal design software utilizing models produced in NONMEM.	Pharmacometrics	no
3798	Lu	Zhang	Uppsala	luzhang1987@gmail.com	Inst för medicinsk biokemi och mikrobiologi	Birgitta Heyman	"Box 582, BMC Uppsala universitet"	75123	Uppsala	english	PhD student	"Immune complexes are composed of antigens, antigen-specific antibodies, and sometimes complement. Such complexes can induce enhanced or suppressed antibody response via the binding of antibodies to B-cell receptors and sometimes Fc- and complement receptors. However, the molecular mechanisms behind this phenomenon are poorly understood. My project is focused on IgG3-mediated enhanced antibody feedback regulation. Murine IgG3, first described by Grey in 1971, constitutes only a small fraction (around 7%) of IgG. It plays an important role in defense against bacteria and fungi. Interestingly, it has an unusual property of cooperative binding, i.e. binding of IgG3 to an antigen surface would facilitate the binding of another IgG3 molecule on it, possibly through Fc-Fc interactions. IgG3 can also self-aggregate and precipitate in the cold. IgG3, like IgM, is an efficient complement activator, acting through both classical and alternative pathway. Our lab reported that IgG3 enhances antibody response equally well in FcRγ-/- mice (lack of FcγRIII, FcγRIV and 80% FcγRI), FcγRIIB-/- mice and FcγRI-/- mice as in wild type mice. However, IgG3 induce an impaired antibody response in C3-depleted and CR1/2 (complement receptor 1 and 2) knock-out mice. It is a poor enhancer of T cell proliferation both in vitro and in vivo. The hypothesis for IgG3-mediated immune enhancement is: the immune complex, formed by antigen, antigen-specific IgG3 and probably cooperative aggregation between IgG3s via Fc-Fc interaction, activates and induces the attachment of complement through the classical pathway. The IgG3-antigen -complement complexes subsequently co-crosslink the B cell receptors to the complement receptors (CR2/CR19 co-receptors), which in turn leads to enhanced antibody response by lowering the threshold of B cell activation. Alternatively, IgG3-antigen-complement may bind to CR2 on follicular dendritic cells. Futher we are going to investigate the distribution of IgG3-mediated antigen inside the follicles."	Immunology	no
3800	Hui	Xu	Uppsala	christofer.xu@gmail.com	IMBIM	Frida henningson	"Uppsala biomedicinska centrum BMC, Husarg. 3"	75123	Uppsala	english	PhD student	"CD23 is the low affinity receptor of IgE, CD23+ B cells can transport IgE-antigen complex to spleen follicle and induce the following antibody enhancement. CD23 belongs to the type II C-type lectin family, which indicate that CD23 can bind to carbohydrates with its lectin head. This project is to test whether CD23 can function as a pattern recognition receptor, to check it can recognise the carbohydrate structure on pathogen surface."	Biological role of CD23 in antigen feedback regulation	no
3801	Wael	Kamel	Uppsala	wael.kamel@imbim.uu.se	IMBIM	Göran Akusjarvi	"BMC, Husargatan 3 C10:3, entance C11 Uppsala"	"BMC, Husargatan 3 C"	Uppsala	english	Phd student	"MicroRNAs constitute a large class of recently discovered short regulatory RNAs that control gene expression post-transcriptionally by binding to the complementary mRNAs and repressing their translation. The importance of the microRNA pathway for regulating gene expression in mammalian cells is already established. Moreover, it has been shown recently that many mammalian viruses can suppress the microRNA pathway, which could suggest that this pathway interferes with virus growth either directly or indirectly. In this project we are attempting to understand and characterize the interaction between adenovirus and microRNA pathway in human cells."	Molecular virology	no
3803	Daniel	Öberg	Uppsala	daniel.oberg@imbim.uu.se	IMBIM	-	Husargatan 3	75123	Uppsala	swedish or English	Guest lecturer	"Using viruses as vectors against cancer, i.e. Oncolytic viruses."	Medical virology	no
3833	Wimal	Ubhayasekera	Uppsala	wimal@xray.bmc.uu.se	worked at IMBIM and expecting to start a new contract at ICM	Jin-ping Li (IMBIM)	"BMC, Box 582"	75123	Uppsala	english	worked as a postdoc	I work on the structural studies of different proteins using homology modeling and protein crystallography approaches. I am a postdoc.	Molecular Biology/protein crystallography	no
3853	Aaron	Shafer	Uppsala	aaron.shafer@ebc.uu.se	Evolutionary Biology	Jochen Wolf	Norbyvagen 18D	75236	Uppsala	english	Postdoctoral Fellow	Comparative genomics of pinnipeds. I will be addressing speciation and demographic questions.	NA	yes
3856	Glib	Mazepa	Uppsala	mazepago@gmail.com	Evolutionary Biology	Jochen Wolf	Norbyägen 18D	75236	Uppsala	english	Master student	I am participating (research training) in hooded crow genome assembly and annotation with further expansion to analysis of alternative splicing.	none	yes
3862	Ingegerd	Elvers	Uppsala	ingegerd.elvers@imbim.uu.se	IMBIM	Kerstin Lindblad-Toh	"BMC, Box 582"	75123	Uppsala	swedish or English	researcher / post doc	"I am currently working at IMBIM, in the mammary tumor project among other things analyzing mRNA seq data."	Molecular Genetics	no